Emergence of resistance to novel β-lactam/β-lactamase inhibitor combinations in KPC-producing Klebsiella pneumoniae: clinical and genomic insights from consecutive bloodstream infections
Resistance to novel BL/BLICs among KPC-producing K. pneumoniae is emerging in Italian hospitals, largely mediated by bla<sub>KPC</sub> variants and porin defects under selective antibiotic pressure. While ATM/AVI, MEM/VAB and IMP/REL remain highly active, resistance to CAZ/AVI is increasingly frequent. Continuous genomic surveillance and optimised antimicrobial stewardship are essential to preserve the efficacy of these last-line agents.
Authors
- Gabriele Bianco (ORCID: https://orcid.org/0000-0002-8180-5075)
- Luisa Guarrasi
- Lisa Pastrone
- Paolo Gaibani (ORCID: https://orcid.org/0000-0003-3791-8635)
- Guido Ricciardelli (ORCID: https://orcid.org/0000-0002-9104-7247)
- Sara Comini
- C. Costa
- Matteo Boattini
- Roberto Casale
- Rossana Cavallo
Institutions
- University of Verona (IT)
- University of Salento (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Azienda Ospedaliera Universitaria Integrata Verona (IT)
- Ospedale Vito Fazzi (IT)
- Carlo Forlanini Hospital (IT)
- University of Turin (IT)
Publication Details
- Journal
- Infection
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1007/s15010-025-02716-4
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59