Paclitaxel-Loaded Polyelectrolyte Nanocarriers: Uptake Mechanisms, Cytotoxicity, and Genotoxicity in Human Endothelial and Breast Cancer Cells
These findings delineate the cellular uptake mechanisms and in vitro biological effects of the examined polyelectrolyte NCs for PTX delivery, with a particular focus on their genotoxicity. Collectively, these in vitro data provide a mechanistic basis to inform the rational design and preclinical optimization of SDS-based NCs, supporting subsequent in vivo evaluation.
Authors
- Marzena Szwed (ORCID: https://orcid.org/0000-0002-2102-3741)
- Katarzyna Bednarska (ORCID: https://orcid.org/0000-0001-6675-0670)
- Agnieszka Marczak (ORCID: https://orcid.org/0000-0003-3439-9032)
- Krzysztof Szczepanowicz (ORCID: https://orcid.org/0000-0002-9927-5869)
- Karol Bukowski (ORCID: https://orcid.org/0000-0003-2517-9898)
- Katarzyna Kania (ORCID: https://orcid.org/0000-0002-0673-596X)
- Anastazja Poczta-Krawczyk (ORCID: https://orcid.org/0000-0003-4940-4965)
Institutions
- University of Łódź (PL)
- Medical University of Lodz (PL)
- Institute for Medical Biology (PL)
- Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences (PL)
- Institute of Biophysics (BG)
Publication Details
- Journal
- Nanotechnology Science and Applications
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/nsa.s560473
- Primary Topic
- Polymer Surface Interaction Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00