Mapping tau spread to long‐range functional and structural connections along the major axes of brain organization
We employed a novel integration of stepwise connectivity and connectome gradients to enable a better understanding of how connectivity is related to tau spread along the major axes of brain organization. We observed widespread network reorganization in AD and notably that the tau-connectivity correlations shifted between major networks of the functional connectome gradient with disease progression.
Authors
- Nesrine Rahmouni
- Jazlynn Xiu Min Tan
- JoAnne McLaurin
- Jean‐Paul Soucy (ORCID: https://orcid.org/0000-0001-6979-1259)
- Sandra E. Black (ORCID: https://orcid.org/0000-0001-7093-8289)
- Maged Goubran (ORCID: https://orcid.org/0000-0001-5880-0818)
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Julie Ottoy (ORCID: https://orcid.org/0000-0002-9879-7497)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Boris C Bernhardt
- Yi‐Hsuan Yeh (ORCID: https://orcid.org/0009-0007-9419-9338)
- Serge Gauthier
- Dr Bojana Stefanovic
- Seok Jun Hong
- Jonah Isen
- Gleb Bezgin
- Min Su (Peter) Kang
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- University of Pittsburgh (US)
- University of Toronto (CA)
- Suwon Research Institute (KR)
- Institute for Basic Science (KR)
- Ontario Brain Institute (CA)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_109745
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00