Coordination of CSF and Peripheral Circulation Proteomics across the AD Spectrum
We identified a set of proteins with altered CSF-plasma gradients in AD, likely reflecting BBB dysfunction and increased CNS-periphery immune interaction. These proteins may offer insights into BBB dysfunction in pre-symptomatic and symptomatic AD, and potentially serve as biomarkers of BBB dynamics throughout disease course.
Authors
- Celeste M M. Karch (ORCID: https://orcid.org/0000-0002-6854-5547)
- Stephanie A. Schultz (ORCID: https://orcid.org/0000-0001-8460-4415)
- Eric B. Dammer (ORCID: https://orcid.org/0000-0003-2947-7606)
- Eric McDade (ORCID: https://orcid.org/0000-0002-6764-3866)
- Carlos C Cruchaga
- Jasmeer P. Chhatwal (ORCID: https://orcid.org/0000-0002-7792-1698)
- Jijing Wang
- Hyun‐Sik Yang
- Erik C.B. Johnson
- Lei Liu
- the Dominantly Inherited Alzheimer Network (DIAN)
Institutions
- Broad Institute (US)
- Harvard University (US)
- Washington University in St. Louis (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Mass General Brigham (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108628
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00