Cell Therapy Ameliorates Cortical Circuit Dysfunction in an Alzheimer's Disease Model
These results suggest that a single administration of MGE precursors to anterior cortex rescued a sleep-dependent brain rhythm. Thus, stem cell therapy is a viable approach for reversing functional deficits in cortical circuits of APP/PS1 mice. This work highlights that stem cell therapy holds promise for Alzheimer's patients to rescue sleep impairments and potentially slow disease progression.
Authors
- Heather M. Brown (ORCID: https://orcid.org/0000-0001-9636-2345)
- Theodore J. Zwang (ORCID: https://orcid.org/0000-0002-6815-4482)
- Megi Maci (ORCID: https://orcid.org/0000-0003-2907-0793)
- Daniel Vogt (ORCID: https://orcid.org/0000-0003-1876-5936)
- Ksenia V. Kastanenka (ORCID: https://orcid.org/0000-0002-3727-0317)
- Janice R. Naegele (ORCID: https://orcid.org/0000-0001-5151-0543)
- Rebecca L. Gillani (ORCID: https://orcid.org/0000-0002-4510-1740)
- Morgan R. Miller (ORCID: https://orcid.org/0000-0002-3740-8144)
- Moustafa Algamal (ORCID: https://orcid.org/0000-0002-6215-0122)
- Stephen J. Perle (ORCID: https://orcid.org/0009-0003-9722-8131)
- Shusaku Takahashi
- Alex Lovely
- Shinya Yokomizo
- April Stafford
- Douglas Richardson
- Linda Liang
Institutions
- Wesleyan University (US)
- Harvard University (US)
- Harvard University Press (US)
- Massachusetts General Hospital (US)
- Michigan State University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_098890
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00