Continuous Time Dynamics of Tau and Depressive Symptoms Across the Alzheimer’s Disease Continuum
In CN older adults, tau accumulation drives worsening depressive symptoms, while higher depressive symptoms in turn facilitate tau accumulation, creating a maladaptive loop. These findings support models proposing that early tau-related disruptions in cognitively unimpaired older adults may contribute to emerging NPS.
Authors
- Jacob M. Hooker (ORCID: https://orcid.org/0000-0002-9394-7708)
- Anne S. Berry (ORCID: https://orcid.org/0000-0002-5086-3643)
- Teodora Markova (ORCID: https://orcid.org/0009-0004-7178-6976)
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- Brandeis University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108212
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00