Theoretical Analysis of Large‐Spot Picosecond Laser Treatment for Pigmented Lesions in Asian Skin

The theoretical analysis shows that at 532 nm, both small and large spot sizes can be effective for treating epidermal lesions. In contrast, at near-infrared wavelengths, smaller spot sizes are preferable for epidermal lesions, whereas larger spot sizes are advantageous for dermal lesions, potentially lowering the risk of complications while maintaining effective target disruption. These findings provide practical clinical guidance by clarifying wavelength- and spot-size-specific strategies according to target depth. Furthermore, the present results may help optimize treatment parameters and device specifications and inform future clinical studies using large-spot picosecond laser systems.