Inflammation‐related proteomic changes in response to amyloid and tau pathologies
Overall, using a multi-omics approach, this preliminary analysis provided new insights on key proteins and molecular inflammatory pathways that co-occur with, and follow the accumulation of, Aβ and tau load along the AD continuum. This analysis will be further expanded and detailed in more cohorts.
Authors
- Henrik Zetterberg
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- Nesrine Rahmouni
- Luiza Santos Machado (ORCID: https://orcid.org/0000-0001-8387-3832)
- Wagner S. Brum (ORCID: https://orcid.org/0000-0002-9777-0559)
- Marco Antônio De Bastiani (ORCID: https://orcid.org/0000-0003-3924-5278)
- Kaj Blennow
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Marisa N. Denkinger (ORCID: https://orcid.org/0000-0002-3696-3795)
- Kübra Tan (ORCID: https://orcid.org/0000-0002-9092-2118)
- Stijn Servaes
- Joseph Therriault
- Eduardo R. Zimmer
- Ilaria Pola
- Andrea L. Benedet
- Guilherme Povala
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Universidade Federal do Rio Grande do Sul (BR)
- University of Pittsburgh (US)
- King's College London (GB)
- Stavanger University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- Centre for Mental Health (GB)
- Profu (Sweden) (SE)
- UK Dementia Research Institute (GB)
- Banner Sun Health Research Institute (US)
- National Hospital for Neurology and Neurosurgery (GB)
- Banner Alzheimer’s Institute
- University College London (GB)
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- McGill University (CA)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_110083
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00