Transcranial Photobiomodulation (tPBM) for Mild Cognitive Impairment (MCI): Key Findings from a Pilot Randomized Clinical Trial (RCT)
Daily, home-based tPBM is a well-tolerated and feasible intervention that led to significant improvements in both cognitive function and biological markers in individuals with MCI. The active tPBM group demonstrated enhanced cognition, recognition memory, and processing speed, alongside reductions in inflammation and structural and functional brain changes, including increased neuroplasticity and alterations in brain connectivity. These findings suggest that tPBM may promote neuronal function and brain network modifications, particularly within the default mode network and limbic regions, providing evidence for its potential as a therapeutic approach in the early stages of Alzheimer's disease.
Authors
- Ori D. Rotstein (ORCID: https://orcid.org/0009-0004-4388-5352)
- Neda Rashidi‐Ranjbar (ORCID: https://orcid.org/0000-0002-2125-1090)
- A. Andreazza
- Simon Graham (ORCID: https://orcid.org/0000-0002-2214-8212)
- Nathan W. Churchill (ORCID: https://orcid.org/0000-0001-8481-2505)
- Tom A. Schweizer (ORCID: https://orcid.org/0000-0003-2278-3539)
- Mirjana Jerkić (ORCID: https://orcid.org/0000-0002-0623-0347)
- Luis Fornazzari
- David G. Munoz (ORCID: https://orcid.org/0000-0001-6027-8870)
- Raphaël Schneider (ORCID: https://orcid.org/0000-0003-1776-2418)
- Reza Zomorrodi
- Corinne E. Fischer
- Lew Lim
Institutions
- St. Michael's Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- Sunnybrook Research Institute
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108308
- Primary Topic
- Laser Applications in Dentistry and Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00