Phase 1b/2a, 6‐month, randomized, double‐blind, placebo‐controlled study of the safety/tolerability and preliminary evidence of efficacy of a tau‐targeted therapeutic in patients with corticobasal syndrome
A stratified "basket trial" design is a viable mechanism to enroll clinical sub-cohorts of corticobasal syndrome to test tau-directed therapeutics in this population.
Authors
- Hilary W. Heuer (ORCID: https://orcid.org/0000-0002-3776-1685)
- B. L. Miller
- Peter Alexander Ljubenkov (ORCID: https://orcid.org/0000-0002-3348-9215)
- Courtney Lane‐Donovan (ORCID: https://orcid.org/0000-0001-9504-8346)
- L. VandeVrede
- Julio C. Rojas (ORCID: https://orcid.org/0000-0002-5730-5388)
- Adam L. Boxer
- Rebecca Snell
Institutions
- University of California, San Francisco (US)
- University Memory and Aging Center (US)
- Global Brain Health Institute (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108915
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00