Aberrant intrinsic functional network connectivity in Early‐Onset Alzheimer’s Disease
In patients with sporadic EOAD, phenotypically vulnerable cortical regions exhibit prominent disruption of intrinsic functional connectivity. Our findings support the selective vulnerability of cortical functional networks in EOAD, which may underlie the distinct pattern of AD pathology spreading and cognitive impairment in this AD clinical phenotype.
Authors
- Alexandra Touroutoglou (ORCID: https://orcid.org/0000-0001-9679-2433)
- Michael Brickhouse
- T. Foroud
- Renaud La Joie (ORCID: https://orcid.org/0000-0003-2581-8100)
- Jeffrey L. Dage (ORCID: https://orcid.org/0000-0002-2192-1699)
- Maria Carrillo
- Kelly Nudelman (ORCID: https://orcid.org/0000-0003-4040-1717)
- Yuta Katsumi (ORCID: https://orcid.org/0000-0003-0413-747X)
- Ani Eloyan (ORCID: https://orcid.org/0000-0002-8110-7680)
- Ryan Eckbo
- Liana G. Apostolova
- Gil D. Rabinovici
- Brad C. Dickerson
Institutions
- Alzheimer's Association (US)
- Harvard University (US)
- University of California, San Francisco (US)
- Brown University (US)
- Massachusetts General Hospital (US)
- University Memory and Aging Center (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_109821
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00