Investigating Hyperactivity in Alzheimer's Disease: Genetic and Dietary Influences in AD‐BXD Mice
This study shows that hyperactivity in AD-BXD mice arises from an interplay of genetic and environmental factors. Diet-specific QTLs on chromosomes 9 and 7 point to candidate genes for AD-related hyperactivity. These loci warrant targeted functional validation and may inform novel interventions for behavioral symptoms in AD.
Authors
- Elissa J. Chesler (ORCID: https://orcid.org/0000-0002-5642-5062)
- Daniel M. Gatti (ORCID: https://orcid.org/0000-0003-0667-9926)
- S. J. Park
- AR Dunn
- Doyeong Hwang (ORCID: https://orcid.org/0000-0002-1452-9023)
- Soonyoung Lee
- Soorin Yim
- Kiyoung Kim
- Kyungwook Lee
- Dongyun Kim
- Kristen MS O'Connell
Institutions
- LG (United States) (US)
- Jackson Laboratory (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108412
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00