Exploring Homocysteine as a Model for Neurodegenerative Diseases: A Focus on Tau Pathology and Sexual Dimorphism

The results align with clinical observations, showing that tau expression does not correlate with symptom severity across sexes. While male rats displayed memory impairments and interleukin changes typical of HHCY and AD, hyperhomocysteinemic females showed less issues in WM performance but elevated p -Tau217 levels. These findings reiforce the sex differences in dementia. Thus, since AD models struggle with sex-specific tau pathology, HHCY could be a useful model for studying tau in females. Supported by INCT (Saúde Cerebral)/CNPq, Brazil.