Lipid-Related Polygenic Risk Score and Its Association With Plaque Rupture Versus Erosion
This is the first study to associate lipid PRSs with specific plaque morphologies, revealing distinct pathogenic mechanisms underlying plaque rupture and erosion. Early genetic risk stratification and subsequent lipid-lowering interventions may provide substantial clinical benefits in mitigating cardiovascular risk, particularly in relation to plaque rupture. Our findings raise questions about the effectiveness of such strategies in preventing plaque erosion, suggesting the need for further investigation into its underlying pathogenesis.
Authors
- Alyssa Grogan (ORCID: https://orcid.org/0000-0002-1505-3311)
- Brady Gaynor (ORCID: https://orcid.org/0000-0002-4142-0613)
- Kazuhiro Fujiyoshi (ORCID: https://orcid.org/0000-0002-9110-4440)
- Takafumi Nakayama (ORCID: https://orcid.org/0000-0003-3529-6238)
- Aloke V. Finn (ORCID: https://orcid.org/0000-0003-0359-0184)
- Teruo Sekimoto (ORCID: https://orcid.org/0000-0002-1054-9406)
- Tomoyo Hamana (ORCID: https://orcid.org/0009-0005-0013-3166)
- Rika Kawakami
- Desiree Williams (ORCID: https://orcid.org/0009-0003-4944-848X)
- T Shiraki
- Anne Turoni-Glitz
- Keisha Medina Diaz
- Yusuke Adachi
- Renu Virmani
- Braxton D. Mitchell
- Takamasa Tanaka
Institutions
- University of Maryland, Baltimore (US)
- Research Institute for Work, Technology and Culture (DE)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1161/atvbaha.125.323942
- Citations
- 1
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 2.01