Association of rare <i>APOE</i> missense variants with Alzheimer's disease in the Japanese population
APOE RMVs were identified in the Japanese population, with two variants showing potential protective effects against AD. Further studies with larger cohorts are needed to validate these findings and to explore the role of APOE RMVs in AD pathology and lipid metabolism.
Authors
- Norikazu Hara (ORCID: https://orcid.org/0000-0001-8525-3469)
- Tamao Tsukie
- Takeshi Ikeuchi
- Kensaku Kasuga (ORCID: https://orcid.org/0000-0002-2178-0769)
- M. Hasegawa (ORCID: https://orcid.org/0000-0001-9234-6014)
- Masataka Kikuchi (ORCID: https://orcid.org/0000-0002-9562-841X)
- Ai Obinata
- Akinori Miyashita
Institutions
- Niigata University (JP)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_098307
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00