Multi-omics profiling reveals an immunosuppressive plasma cell subset within tertiary lymphoid structures in cervical cancer
We identified distinct plasma cell subsets in CC and found that HSPA1B_PC are enriched in tumors, associated with immunosuppressive T cells in TLS. These findings suggest that HSPA1B_PC contribute to an immunosuppressive microenvironment in CC, highlighting their potential as therapeutic targets.
Authors
- Wenhui Yang (ORCID: https://orcid.org/0000-0001-5740-1364)
- Chao Liu (ORCID: https://orcid.org/0000-0001-8683-3473)
- Fuhao Wang (ORCID: https://orcid.org/0009-0008-3636-1437)
- Qian Huang
- Qi An (ORCID: https://orcid.org/0009-0001-0769-4282)
- Shengqin Yue
- Wenxue Zou
- Xiaohui Li
- Tianyu Lei
- Xia Li
- Cong Wang
- Zhou Huang
- Qinyong Hu
- Qian Wang
- Bicheng Zhang
Institutions
- Peking University (CN)
- Wuhan University (CN)
- Peking University Cancer Hospital (CN)
- Linyi People's Hospital (CN)
- Shandong Tumor Hospital (CN)
- Peking University First Hospital (CN)
- Heze Municipal Hospital (CN)
- Renmin Hospital of Wuhan University (CN)
- Shandong First Medical University (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1007/s00262-025-04268-w
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Chinese Medical Association
- Wuhan University