Sex differences in tau and synaptic pathologies in a humanized MAPT mouse model revealed by PET imaging
PET imaging revealed more rapid tau and synaptic pathologies in female S305Ns despite greater cognitive deficits in male S305N mice. Pathological assessment for neurodegeneration is ongoing. Further characterization of [<sup>18</sup>F]OXD-2314 and [<sup>18</sup>F]SynVesT-1 in tauopathy mouse lines will support our PET imaging studies with these radiopharmaceuticals in patients with tauopathy.
Authors
- Wai Haung Yu (ORCID: https://orcid.org/0000-0001-7186-6731)
- Mohammad Alijaniaram
- Anton Lindberg (ORCID: https://orcid.org/0000-0002-0076-8517)
- Junchao Tong
- Darcy Wear
- Sahana Kunanayagam
- Neil Vasdev
- Christopher D Morrone
Institutions
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_110229
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00