Trusting behavior associated with reduced white matter integrity in uncinate fasciculus in Alzheimer’s disease and behavioral variant frontotemporal dementia

Our results suggest a distinct relationship between reduced white matter integrity in the UF and trusting behaviors in dementia patients and show that bvFTD patients are less cooperative overall than AD patients. These findings align with prior studies investigating the socioemotional sensitivity of the uncinate fasciculus, further suggesting that UF damage may contribute to behavioral symptoms such as impaired prosocial cooperation and trust.