Lecanemab therapy Leads to Glymphatic Function Maintenance and Free Water Homeostasis in Alzheimer’s Disease: Evidence from a Multidimensional Real‐World Study
Short-term Lecanemab stabilizes glymphatic function, reduces FW of temporo-limbic region, and associates with cognitive benefits partially mediated by FW. Baseline glymphatic integrity may predict a therapeutic response, highlighting its role in anti-amyloid therapies.
Authors
- Xiaoyan Li (ORCID: https://orcid.org/0000-0002-8874-5634)
- Chao Gao (ORCID: https://orcid.org/0000-0002-7954-024X)
- Yi Tang (ORCID: https://orcid.org/0009-0008-8185-5962)
- Ruinan Shen
- Huizhu Zhong
- Qiao Wei
- Lingyun Chen
- Jun Liu
- Wenyan Kang
Institutions
- Ruijin Hospital (CN)
- Eisai (Japan) (JP)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108148
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00