Brain Structure in Type 2 Diabetics with High Visceral Adiposity
Individuals with type 2 diabetes mellitus and higher amounts of visceral fat exhibited lower volumes in whole brain parenchyma and regions vulnerable to Alzheimer's disease. These findings suggest that type 2 diabetes and visceral obesity may be important targets for secondary prevention of AD as early as midlife. The public health implications are significant, as these conditions are modifiable through behavioral and pharmacological interventions, potentially offering a promising approach to mitigating AD risk.
Authors
- Rodrigo Solis Pompa
- Saurabh Garg (ORCID: https://orcid.org/0000-0001-8719-284X)
- Yosef Gavriel Chodakiewitz
- Somayeh Meysami (ORCID: https://orcid.org/0000-0001-8550-1397)
- David A. Merrill (ORCID: https://orcid.org/0000-0003-2181-3839)
- Cyrus A. Raji (ORCID: https://orcid.org/0000-0002-9086-0105)
- Thanh D. Nguyen (ORCID: https://orcid.org/0000-0002-1411-7694)
- Saqib Basar
- Nasrin Akbari
- Sam Hashemi
- Soojin Lee
- Amar Patel
- Ahmed Gouda
- Daniel J. Durand
Institutions
- Palo Alto University (US)
- Washington University in St. Louis (US)
- Mallinckrodt (United States) (US)
- Saint John's Health Center (US)
- Pacific Heart Institute (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_109899
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00