Darunavir analog precursors target mitochondrial metabolism in multiple myeloma and CLL.
BupM-NH2, and particularly BnpM-NH2, showed enhanced cytotoxicity against MM, CLL, and NDMM cells compared to PBMCs by inducing apoptosis through autophagy and mitochondrial respiration inhibition. While the cytotoxic effect in RRMM is less pronounced and nonsignificant, BupM-NH2 and BnpM-NH2 induces stress in respiratory chain and mitochondria, which may re-sensitize resistant tumor cells to treatments. Therefore these compounds may hold promise as novel therapeutic agents for MM and CLL treatment.
Authors
- Maria Francesca Armentano (ORCID: https://orcid.org/0000-0001-5607-5288)
- Teodora Statuto
- Paolo Lupattelli (ORCID: https://orcid.org/0000-0001-5404-041X)
- Maria Funicello (ORCID: https://orcid.org/0000-0003-1104-3439)
- Marisabel Mecca (ORCID: https://orcid.org/0000-0003-2100-6981)
- Lucia Chiummiento (ORCID: https://orcid.org/0000-0001-8181-9138)
- Salvatore Cortellino (ORCID: https://orcid.org/0000-0001-8331-3800)
- Luciana Valvano (ORCID: https://orcid.org/0000-0002-6382-7318)
- Enrico La Spina (ORCID: https://orcid.org/0000-0002-8483-4680)
- Marzia Sichetti (ORCID: https://orcid.org/0000-0003-3046-7691)
- Alessandro Santarsiere (ORCID: https://orcid.org/0009-0009-2580-1414)
- Simona Picerno
- Martina Giuseffi (ORCID: https://orcid.org/0009-0002-7749-8479)
- Antonio Giordano (ORCID: https://orcid.org/0000-0002-7760-9717)
- Eugenia Giglio (ORCID: https://orcid.org/0009-0007-8351-5876)
- Alessandra Romano
Institutions
- University of Siena (IT)
- Yahoo (United Kingdom) (GB)
- University of Basilicata (IT)
- University of Catania (IT)
- Centro di Riferimento Oncologico della Basilicata (IT)
- Scuola Superiore Meridionale (IT)
- Temple University (US)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1186/s12935-025-04142-w
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.00