The Gut Microbiome at the Onset of Inflammatory Bowel Disease: A Systematic Review and Unified Bioinformatic Synthesis
Core microbial perturbations at onset of CD and UC are depletion of anaerobes and enrichment of oxygen-tolerant, orally associated bacteria. As we place greater emphasis on early diagnosis and prediction of IBD risk, this finding may support innovative diagnostic approaches. Microbiome-targeted intervention and alteration of luminal oxygen availability may offer novel therapeutic avenues for new-onset patients and identified high-risk groups.
Authors
- Morris A. Gordon (ORCID: https://orcid.org/0000-0002-1216-5158)
- Gregor Scott
- Nikhil Narayan Pai
- Ken Croitoru
- Georgina L. Hold (ORCID: https://orcid.org/0000-0001-7573-3397)
- Hana Čipčić Paljetak (ORCID: https://orcid.org/0000-0002-8837-3156)
- Shivani Kansal
- Richard Hansen
- Fan Zhang
- Johan Van Limbergen
- Ting Zhang
- Peter Lewindon
- James Ashton
- Peter Rimmer
- Rotem Sigall-Boneh
- Mohammed Nabil Quraishi
- Tariq H. Iqbal
Institutions
- University of Dundee (GB)
- University of Lancashire (GB)
- Queen Elizabeth Hospital Birmingham (GB)
- NHS Greater Glasgow and Clyde (GB)
- UNSW Sydney (AU)
- University of Birmingham (GB)
Publication Details
- Journal
- Gastroenterology
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1053/j.gastro.2025.09.014
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00