PLVAP mediates the regulation of the tumour microenvironment in early‐stage lung adenocarcinoma
Tip cells expand during early LUAD progression and likely originate from capillary type I endothelial cells. Tumour-derived TGFβ1 induces PLVAP expression in endothelial cells, linking tumour signals to vascular activation. PLVAP enhances endothelial cell migration, invasion and angiogenic capacity. Endothelial PLVAP promotes tumour cell invasiveness, revealing a reciprocal endothelial-tumour interaction that drives early tumour progression.
Authors
- Jun Yin
- Charles A. Powell (ORCID: https://orcid.org/0000-0003-3509-891X)
- Linshan Xie (ORCID: https://orcid.org/0009-0009-3700-4420)
- F R Hirsch
- Chunxue Bai
- Xiangdong Wang (ORCID: https://orcid.org/0009-0001-2194-4356)
- Yan Zhang (ORCID: https://orcid.org/0000-0001-7746-0003)
- Jinjie Yu
- Yujie Zheng (ORCID: https://orcid.org/0009-0000-9122-4621)
- Hui Kong
- Zeyuan Yu (ORCID: https://orcid.org/0000-0002-6462-8417)
- Mengting Sun
- Jian Zhou
- Hongyi Xin
- Jie Hu
- Shaohua Lu
- Yuanlin Song
- Dawei Yang
Institutions
- Mount Sinai Health System (US)
- Shanghai Medical College of Fudan University (CN)
- University of Shanghai for Science and Technology (CN)
- Sun Yat-sen University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Shanghai Medical Information Center (CN)
- Shanghai FRP Research Institute (China) (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Zhongshan Hospital (CN)
- Tisch Hospital (US)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shanghai Center For Bioinformation Technology (CN)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/ctm2.70532
- Citations
- 1
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Fudan University
- National Science and Technology Major Project