Molecular hallmarks of cognitive resilience and resistance in Alzheimer's disease: Insights from excitatory and inhibitory neurons
This study reveals cellular and molecular features of cognitive resilience, highlighting the roles of excitatory and inhibitory neurons, protein folding pathways, and protective signaling networks. Our observations expose that the excitatory-inhibitory balance, which is disrupted in AD, is maintained in resilience. Our findings provide a foundation for leveraging resilience mechanisms to develop targeted therapies for AD.
Authors
- Doo Yeon Kim (ORCID: https://orcid.org/0000-0002-6969-0340)
- Athanasios Ploumakis
- Isabel Castanho (ORCID: https://orcid.org/0000-0003-1413-626X)
- Christoph Lange (ORCID: https://orcid.org/0000-0002-9691-4741)
- Sarah L. Morgan (ORCID: https://orcid.org/0000-0002-1734-4710)
- Nikolaos Kalavros (ORCID: https://orcid.org/0000-0001-5503-9808)
- Carles A. Boix (ORCID: https://orcid.org/0000-0001-9212-856X)
- R E Tanzi
- Saloni Shah (ORCID: https://orcid.org/0000-0002-1483-4562)
- Lars Bertram
- Giulia Pegoraro (ORCID: https://orcid.org/0009-0001-5206-5303)
- Bartholomew White
- Pourya Naderi Yeganeh
- Winston Hide
- Manolis Kellis
- Li‐Huei Tsai
- David A. A. Bennett
- Hansruedi Mathys
- Dmitry Prokopenko
- Larisa M. Soto
Institutions
- Broad Institute (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Queen Mary University of London (GB)
- University of Pittsburgh (US)
- University of Oslo (NO)
- University of Exeter (GB)
- Massachusetts General Hospital (US)
- Rush University (US)
- Massachusetts Institute of Technology (US)
- University of Lübeck (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_096285
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00