Rates of Progression to Tau‐PET Positivity in Preclinical Alzheimer’s Disease
Only one in three Aβ-positive CU individuals with a negative tau-PET scan will progress to tau-PET positivity within five years. Combining blood-based and imaging biomarkers may improve identification of individuals at higher risk for tau accumulation, which may inform future prevention trial design.
Authors
- Michel J. Grothe (ORCID: https://orcid.org/0000-0003-2600-9022)
- David M. Cash (ORCID: https://orcid.org/0000-0001-7833-616X)
- Alexis Moscoso (ORCID: https://orcid.org/0000-0003-0170-036X)
- Michael Schöll (ORCID: https://orcid.org/0000-0001-7800-1781)
- Stamatia Karagianni (ORCID: https://orcid.org/0009-0006-2505-770X)
- Jesús Silva‐Rodríguez
- Anxo M. Minguillón Pereiro
- Pablo Aguiar
Institutions
- Sahlgrenska University Hospital (SE)
- Complejo Hospitalario Universitario de Santiago (ES)
- Center for Research in Molecular Medicine and Chronic Diseases (ES)
- UK Dementia Research Institute (GB)
- Instituto de Investigación Sanitaria de Santiago (ES)
- National Hospital for Neurology and Neurosurgery (GB)
- Fundacion Centro De Investigacion De Enfermedades Neurologicas (ES)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108962
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00