Evaluation of antiulcer activity of Launaea nudicaulis (L.) Hook.f (Gojihva) in experimental rat models

The study aimed to evaluate the antiulcer activity of a 50% hydroalcoholic extract of Launaea nudicaulis (L.) Hook.f (LN) using two experimental rat models: aspirin-induced gastric ulcer and aspirin plus pylorus ligation-induced gastric ulcer. The hydroalcoholic extract of LN was prepared using Soxhlet extraction. Wistar rats were randomly divided into groups (6 animals per group) and treated with vehicle, LN extract at doses of 100, 200, and 400 mg/kg, or reference standards (omeprazole and sucralfate) for 7 days. Gastric ulceration was induced using aspirin or aspirin plus pylorus ligation models. Parameters such as ulcer index, total acidity, gastric juice volume, pH, Biochemical markers (SOD, TC, TP, TC:TP) and histopathological changes were evaluated. Statistical analysis was conducted using one-way ANOVA and post hoc, with significance ranging from P < 0.05 to P <0.001. The hydroalcoholic extract of LN demonstrated dose-dependent antiulcer activity. At 400 mg/kg, the extract significantly reduced the ulcer index, total acidity, and gastric juice volume while increasing gastric pH compared to the control group. Biochemical markers showed a modest improvement with treatment. And Histopathological analysis confirmed reduced gastric lesions and inflammation in treated groups. The 50% hydroalcoholic extract of LN exhibited potent antiulcer activity comparable to omeprazole and sucralfate, supporting its traditional use in gastrointestinal disorders. • Hydroalcoholic extract of Launaea nudicaulis (L.) Hook.f (HELN) was evaluated for its antiulcer potential in Wistar rats. • Aspirin and aspirin + pylorus ligation models were used to induce gastric ulcers. • HELN significantly reduced ulcer index, acidity, and gastric juice volume. • It enhanced gastric pH, SOD levels, and mucosal protection (TC:TP ratio). • HELN showed comparable efficacy to omeprazole and sucralfate in healing ulcers.