Long-term change in body composition following intentional weight loss and its effect on physical function
Although the overall intervention effect on physical function was positive, increases in fat mass were associated with poorer physical performance while lean mass loss was associated with weaker strength 8 years post-randomization. Findings highlight the importance of minimizing fat mass gain/regain and loss of lean mass during intentional weight loss.
Authors
- Kristen M. Beavers (ORCID: https://orcid.org/0000-0002-7786-4195)
- Rebecca H. Neiberg (ORCID: https://orcid.org/0000-0003-0719-6520)
- Ariana M. Chao (ORCID: https://orcid.org/0000-0001-5633-8973)
- Kacey Chae (ORCID: https://orcid.org/0009-0008-2785-2947)
- James O. Hill (ORCID: https://orcid.org/0000-0003-4690-2264)
- John M. Jakicic (ORCID: https://orcid.org/0000-0001-6800-9368)
- Xiaoyan Leng (ORCID: https://orcid.org/0000-0002-7610-7977)
- Denise K. Houston (ORCID: https://orcid.org/0000-0002-3355-4304)
- Henry J. Pownall (ORCID: https://orcid.org/0000-0001-8412-506X)
- GA Bray
- Stephen B. Kritchevsky
- Karen C. Johnson
Institutions
- Pennington Biomedical Research Center (US)
- Louisiana State University (US)
- Houston Methodist (US)
- Johns Hopkins University (US)
- University of Tennessee Health Science Center (US)
- Baylor College of Medicine (US)
- Johns Hopkins Medicine (US)
- University of Alabama at Birmingham (US)
- Methodist Hospital (US)
- University of Kansas Medical Center (US)
- Wake Forest University (US)
Publication Details
- Journal
- International Journal of Obesity
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1038/s41366-025-01997-x
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00