Can Antipsychotics Be the Reason for Developing Alzheimer's Disease in Schizophrenic Patients? : A Novel perspective

Dopamine antagonists, the standard drugs for treating schizophrenia, might contribute to inducing Alzheimer's disease in patients since dopaminergic dysregulation underlies both diseases. The observation represents a call for investigating the mechanisms by which antipsychotics influence neurodegeneration more thoroughly and to come up with improved options with fewer cognitive side effects.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70861_108838
Primary Topic
Schizophrenia research and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Can Antipsychotics Be the Reason for Developing Alzheimer's Disease in Schizophrenic Patients? : A Novel perspective

Amira A. Shahin, Mohamed Khaled Ali Mohamed Ali Zid, Ahmed Hussein Mohamed Ismail Kira, Mohamed Hosni Kamel Elkellawi
Alzheimer s & Dementia
Schizophrenia research and treatment
article

Can Antipsychotics Be the Reason for Developing Alzheimer's Disease in Schizophrenic Patients? : A Novel perspective

Amira A. Shahin, Mohamed Khaled Ali Mohamed Ali Zid, Ahmed Hussein Mohamed Ismail Kira, Mohamed Hosni Kamel Elkellawi
article en

Abstract

Dopamine antagonists, the standard drugs for treating schizophrenia, might contribute to inducing Alzheimer's disease in patients since dopaminergic dysregulation underlies both diseases. The observation represents a call for investigating the mechanisms by which antipsychotics influence neurodegeneration more thoroughly and to come up with improved options with fewer cognitive side effects.

Alzheimer s & DementiaVol. 21(S7)
Cairo University (EG)
Openalex Percentile: Top 36%
Schizophrenia research and treatment
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