Modification of Physico-Chemical and Biological Characteristics of Polymethylmethacrylate with Amorphous Carbon Nanoparticles for Counteracting Healthcare-Associated Infections

Composite materials based on polymethylmethacrylate (PMMA) and carbon nanoparticles are used in aviation, construction, medical and other fields of activity. Carbon nanotubes and carbon nano-dots are mainly used as carbon nanoparticles. Both carbon nanotube and carbon nano-dots are difficult to obtain materials with considerable cost. Amorphous carbon nanoparticles, on the contrary, are easy to obtain and have a low cost. The purpose of this work is to study the physico-chemical and biological characteristics of polymethylmethacrylate modified with amorphous carbon nanoparticles. Laser ablation was used to obtain the nanoparticles. Dynamic light scattering, measurement of the electrokinetic potential, TEM, AFM, and Raman microscopy are used to characterize nanoparticles. FTIR, MIM, AFM, UV-visual diagnostics, ROS tests, and biopolymer regeneration tests were used to analyze the combined sensors. The bacteriostatic effect was evaluated using turbodimetry, and the antibacterial effect was evaluated using precision cytofluorometry. Mammalian cells were examined using fluorescence microscopy. Carbon nanoparticles (CNPs) have been obtained and characterized. A protocol has been developed for the introduction of CNPs into photolithographic resin. Printed samples of complex geometry. It is shown that the printed samples are amenable to polishing, have pro-oxidant properties, and are able to prevent damage to biopolymers. Printed samples inhibit the development of bacteria and cause loss of viability. At the same time, the printed samples do not affect the development of mammalian cells. The obtained resins based on PMMA with CNPs can potentially serve as the basis for the creation of non-toxic materials in biomedicine and pharmacology.