Hormone replacement therapy in women and vascular risk factors modify the association of a multi‐ancestry polygenic risk score with Alzheimer disease and related traits

Our findings demonstrate the utility of an ancestry-aware PRS for advancing understanding of AD in diverse populations. Future research incorporating AD PRS in studies of sex-specific, vascular, and hormonal risk factors may offer promise for personalized interventions and prevention strategies for AD.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70861_108536
Primary Topic
Genetic Associations and Epidemiology
Type
article
Field-Weighted Citation Impact
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article

Hormone replacement therapy in women and vascular risk factors modify the association of a multi‐ancestry polygenic risk score with Alzheimer disease and related traits

Nuzulul Kurniansyah, R. Mayeux, R. Au, Habbiburr Rehman et al.
Alzheimer s & Dementia
Genetic Associations and Epidemiology
article

Hormone replacement therapy in women and vascular risk factors modify the association of a multi‐ancestry polygenic risk score with Alzheimer disease and related traits

Nuzulul Kurniansyah, R. Mayeux, R. Au, Habbiburr Rehman, Annie Lee, Logue Ma, Lisa Laverne Barnes, Sterling C. Johnson, Bush Wh, Li‐San Wang, Adam M Brickman, Congcong Zhu, Shinya Tasaki, John J. Farrell, Victoria C. Merritt, Rui Zhang, Jesse Mez, Lindsay A. Farrer, Jonathan L Haines, Joanne M Murabito, Paul K Crane, Richard Sherva, Richard L. Hauger, Matthew S. Panizzon, Kun Ho Lee, Carlos Cruchaga, Kathryn L. Lunetta, David A. A. Bennett, Margaret Pericak‐Vance, J. Michael Gaziano, Ricardo A Vialle
article en

Abstract

Our findings demonstrate the utility of an ancestry-aware PRS for advancing understanding of AD in diverse populations. Future research incorporating AD PRS in studies of sex-specific, vascular, and hormonal risk factors may offer promise for personalized interventions and prevention strategies for AD.

Alzheimer s & DementiaVol. 21(S7)
Boston University (US), Brigham and Women's Hospital (US), Rush University Medical Center (US), Boston Medical Center (US), University of Miami (US), Chosun University (KR), Vanderbilt University (US), University of Washington (US), Washington University in St. Louis (US), Columbia University Irving Medical Center (US), VA Boston Healthcare System (US), University of California San Diego (US), Joint Center for Structural Genomics (US), VA San Diego Healthcare System (US), National Center for PTSD (US), Framingham Heart Study (US), NeoGenomics (United States) (US), Korea Brain Research Institute (KR), Case Western Reserve University (US), Columbia University (US), Gwangju University (KR), University of Pennsylvania (US), Vanderbilt University Medical Center (US)
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Openalex Percentile: Top 25%
Genetic Associations and Epidemiology
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