Association of neighbourhood walkability with pathophysiological markers and depressive symptoms by area deprivation index and cognitive status in older adults
Our findings link neighbourhood walkability to neurodegeneration, as well as neuroinflammation and depressive symptoms in highly and moderately deprived areas and to lower Aβ in individuals with a dementia diagnosis. Future research should explore the mediating mechanisms linking walkability to brain and mental health, including physical activity and mental health promotion. Urban planning strategies may consider both walkability and neighbourhood socioeconomic context to optimize cognitive and mental health outcomes in aging populations.
Authors
- Eleni Palpatzis (ORCID: https://orcid.org/0000-0001-8478-273X)
- Antònia Valentín (ORCID: https://orcid.org/0000-0002-9275-7101)
- Sami Petricola (ORCID: https://orcid.org/0000-0002-0432-0664)
- Alexandre Bejanin (ORCID: https://orcid.org/0000-0002-9958-0951)
- Juan M. Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- Alberto Lleó
- María Franquesa‐Mullerat (ORCID: https://orcid.org/0009-0006-1484-7132)
- Alex López
- Pablo Aguilar
- Eider M Arenaza‐Urquijo
- Carmen M Colceriu
- Sara E Zsadanyi
Institutions
- Universitat Autònoma de Barcelona (ES)
- Universitat Pompeu Fabra (ES)
- Instituto de Salud Carlos III (ES)
- Hospital de Sant Pau (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Fundació Catalana per a la Recerca i la Innovació (ES)
- Barcelona Institute for Global Health (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_105259
- Primary Topic
- Older Adults Driving Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00