Multimodal Atlas of Caudate Head Reveals Impact of pTau Burden on Resident Glial Cells
AD's impact in caudate head contrasts with established effects on the cortex. Regionally unique increases in certain non-neuronal populations suggest a caudate specific response to AD. Additionally, little neuronal loss, even with respect to significant pTau pathology suggests either environmental or cellular factors that confer resilience, or distinct pTau conditions in the caudate. Finally, our data suggests that the predominantly diffuse plaques in caudate are not sufficient for a plaque induced response in microglia.
Authors
- Delissa McMillen (ORCID: https://orcid.org/0000-0002-3413-4424)
- Jennie Close (ORCID: https://orcid.org/0000-0001-9234-5855)
- Amy Torkelson (ORCID: https://orcid.org/0000-0002-9465-4202)
- Rushil Chakrabarty (ORCID: https://orcid.org/0000-0003-1722-8557)
- Naomi Martin (ORCID: https://orcid.org/0000-0002-0034-1628)
- Nasmil Valera Cuevas (ORCID: https://orcid.org/0000-0002-9846-3796)
- Ming Xiao (ORCID: https://orcid.org/0000-0001-5528-9102)
- Erica J. Melief (ORCID: https://orcid.org/0000-0002-3570-3289)
- Jeff Goldy (ORCID: https://orcid.org/0000-0001-5140-6922)
- Michael Tieu (ORCID: https://orcid.org/0000-0001-9286-5623)
- Mariano I. Gabitto (ORCID: https://orcid.org/0000-0001-6911-344X)
- Nadia Postupna (ORCID: https://orcid.org/0000-0002-4939-4915)
- Jeremy Miller (ORCID: https://orcid.org/0000-0001-5513-9622)
- Anish Bhaswanth Chakka (ORCID: https://orcid.org/0000-0002-1095-1817)
- Christina Alice Pom (ORCID: https://orcid.org/0000-0001-9057-040X)
- Emily Gelfand (ORCID: https://orcid.org/0000-0003-2175-5894)
- Kimberly A. Smith (ORCID: https://orcid.org/0000-0002-3142-1970)
- Jeanelle Ariza (ORCID: https://orcid.org/0000-0002-0829-7887)
- Augustin Ruiz (ORCID: https://orcid.org/0000-0003-2633-2495)
- Paul Olsen (ORCID: https://orcid.org/0000-0001-8132-3722)
- Alana Oyama (ORCID: https://orcid.org/0000-0002-4492-0533)
- Omar Kana (ORCID: https://orcid.org/0000-0002-7772-4694)
- Eitan S Kaplan (ORCID: https://orcid.org/0000-0002-9355-324X)
- Darren Bertagnolli (ORCID: https://orcid.org/0000-0002-6626-1567)
- Stuard Barta (ORCID: https://orcid.org/0000-0001-7180-3466)
- Angela Ayala (ORCID: https://orcid.org/0009-0002-8512-6851)
- Michael Hawrylycz
- Tejas Bajwa
- Joseph T Mahoney
- Kyle J Travaglini
- Josh Nagra
- Rebecca Ferrer
- Rebecca D Hodge
- C. Dirk Keene
- Ed S Lein
- Brian Long
- Alvin Huang
- Madeline Bixby
- Andreas Tjaernberg
- Junitta Guzman
- Thanh Cardenas
Institutions
- Allen Institute for Brain Science (US)
- University of Washington (US)
- Allen Institute (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_109003
- Primary Topic
- Neurological and metabolic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00