Inflammation and verbal episodic memory correlate with bilateral salpingo‐oophorectomy in early midlife
Women with early BSO both taking and not taking ET showed no significant elevations in inflammatory protein markers, suggesting an absence of chronic systemic inflammation in early midlife. ET correlated with reduced chemokine expression and reduced neutrophil and monocyte recruitment systemically, suggesting anti-inflammatory mechanisms. Other known markers associated with cognitive decline, including c-reactive protein (CRP), were not included in the panel, however this study widens the scope of inflammatory markers studied. The correlation between reduced PC2 and verbal retention suggests a possible role of inflammation in cognition.
Authors
- Noelia Calvo (ORCID: https://orcid.org/0000-0003-4202-9314)
- Sophia Zhao (ORCID: https://orcid.org/0009-0008-6914-3583)
- Alana Brown (ORCID: https://orcid.org/0000-0002-1237-1314)
- Preben Kjølhede (ORCID: https://orcid.org/0000-0001-5702-4116)
- Laura L. Gravelsins (ORCID: https://orcid.org/0000-0002-9087-9199)
- Elisabet Classon (ORCID: https://orcid.org/0000-0003-1403-6357)
- Gillian Einstein (ORCID: https://orcid.org/0000-0002-0770-5471)
- Shreeyaa Ramana (ORCID: https://orcid.org/0009-0006-9010-6184)
- Elvar Theodorsson
- Shannon Dunn
- Emily Pullen
Institutions
- Linköping University (SE)
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- Women's College Hospital (CA)
- Baycrest Hospital (CA)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108904
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00