Do epigenetic age‐acceleration estimators predict survival to age 90 with preserved cognition? The Women's Health Initiative Memory Study (WHIMS)
EAA measures consistently predict survival to age 90 in older women, however they do not differentially predict survival with vs. without intact cognition. These findings support the further development of EAA measures trained on preserved cognitive status at advanced ages.
Authors
- Linda K. McEvoy (ORCID: https://orcid.org/0000-0003-4583-7798)
- Kenneth B. Beckman (ORCID: https://orcid.org/0000-0001-8876-0706)
- Stephen R. Rapp (ORCID: https://orcid.org/0000-0002-9766-3104)
- M. A. Espeland
- Bowei Zhang (ORCID: https://orcid.org/0000-0002-3120-4538)
- Aladdin H. Shadyab
- Ake Lu
- Steve Horvath
- Steve Nguyen
- Adam Maihofer
- Andrea Z. LaCroix
- Susan M. Resnick
- Caroline Nievergelt
Institutions
- National Institutes of Health (US)
- University of Minnesota (US)
- Kaiser Permanente Washington Health Research Institute (US)
- University of California San Diego (US)
- Cambridgeshire County Council (GB)
- National Institute on Aging (US)
- Wake Forest University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_099854
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00