Distribution Features and Antimicrobial Resistance Trends of Clinical Pathogens: A Retrospective Study in a Tertiary Teaching Hospital in East China (2020−2024)

<i>E. coli, K. pneumoniae</i>, and <i>P. aeruginosa</i> were the predominant pathogens in this hospital. The rising and high resistance rates of CRKP and CRAB highlight the urgent need for enhanced antimicrobial stewardship. Β-lactamase, β-lactamase inhibitor combination preparations and carbapenems were recommended for susceptible strains of <i>E. coli</i> and <i>K. pneumoniae</i>. For CRKP infections and CRAB infections, tigecycline and colistin are recommended. Continuous surveillance and infection control are crucial to combat the evolving threat of multidrug-resistant organisms.