Treatments for Depression and the Risk of Dementia: A 23‐Year Cohort Study Using Akrivia Health Secondary Mental Healthcare Data
This study showed that antidepressants, especially MAOIs and TCAs, are linked to an increased risk of dementia. The increased risk may be due to anticholinergic effects of antidepressants as well as residual confounding due to depression severity. Further research is needed to understand the underlying mechanisms and help clinicians balance the benefits of depression treatment with the risk of dementia.
Authors
- J. Harrison (ORCID: https://orcid.org/0000-0002-5775-2524)
- Benjamin Fell
- Panagiota Kontari (ORCID: https://orcid.org/0000-0002-6652-4750)
- William Pettersson‐Yeo
- Maxime Taquet (ORCID: https://orcid.org/0000-0002-8987-952X)
- Ana Todorovic
Institutions
- Oxford Health NHS Foundation Trust (GB)
- IQVIA (United Kingdom) (GB)
- University of Oxford (GB)
- Science Oxford (GB)
- Newcastle University (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108228
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00