Interchangeability of Centiloid values from different research and commercial software using [ <sup>18</sup> F]flutemetamol PET images
CL values from most software pairs were interchangeable within the range of test-retest variations, with high overall group-level agreement. Ideally, all inter-pipeline LoAs should be reduced to a similar level as test-retest. Inter-software reliability in dichotomization was >92% for scans across a wide range of CL values, but the percentage was lower for scans with amyloid loads closer to the range of typical positivity thresholds. Uncertainty estimates should always be considered when interpreting results.
Authors
- Vincent Doré (ORCID: https://orcid.org/0000-0002-8051-0558)
- Ariane Bollack (ORCID: https://orcid.org/0000-0002-9169-7530)
- Lennart Thurfjell
- Rachid Fahmi (ORCID: https://orcid.org/0000-0001-8277-6125)
- Elena M. Bonke (ORCID: https://orcid.org/0000-0002-8547-7283)
- Gill Farrar (ORCID: https://orcid.org/0000-0002-0726-723X)
- Oskar H. Hansson
- Mark Battle
- Christopher Buckley
- Pierrick Bourgeat
- Jurgen Fripp
- Christopher Page
- Adam J. Schwarz
- William Balhorn
- Mike Haas
Institutions
- Commonwealth Scientific and Industrial Research Organisation (AU)
- Tampere University of Applied Sciences (FI)
- Lund University (SE)
- General Electric (Spain) (ES)
- Buckinghamshire Healthcare NHS Trust (GB)
- Tampere University (FI)
- Australian e-Health Research Centre (AU)
- RHAMM Technologies (United States) (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_110090
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00