Gut Microbiome Diversity as a Mediator Between Life's Essential 8 Adherence and Cognitive Function
This study highlights the interconnected relationship between cardiovascular health, gut microbiome diversity, and cognitive function. Higher adherence to LE8 was associated with favorable microbial profiles and better cognitive performance, with the gut microbiome serving as a critical mediator. These findings emphasize the importance of integrated lifestyle interventions that address cardiovascular and cognitive health simultaneously. To validate these results and refine therapeutic strategies, future research should prioritize longitudinal studies and randomized controlled trials that explore the causal pathways and clinical applications of these findings.
Authors
- Ramachandran Srini Vasan (ORCID: https://orcid.org/0000-0001-7357-5970)
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Yannick N. Wadop (ORCID: https://orcid.org/0000-0002-8955-1874)
- Tiffany F. Kautz (ORCID: https://orcid.org/0000-0001-7680-4708)
- Bernard Fongang (ORCID: https://orcid.org/0000-0002-8161-1553)
- Jazmyn A Muhammad
- Rebecca Bernal
- Jayandra J. Himali
- Claudia L. Satizabal
- Alexa S Beiser
Institutions
- Boston University (US)
- Boston Medical Center (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of Massachusetts Boston (US)
- Institute for Neurodegenerative Disorders (US)
- Framingham Heart Study (US)
- The University of Texas at San Antonio (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_103169
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00