Localized therapeutic strategy based on microRNA-21-loaded mesoporous silica nanoparticles hydrogel improves bone repair in medication-related osteonecrosis of the jaw
The miR-21-loaded MSN hydrogel effectively restored bone remodeling and healed MRONJ defects without systemic toxicity, offering a promising localized adjunct to anti-resorptive therapies.
Authors
- Siyuan Huang (ORCID: https://orcid.org/0000-0002-8292-6477)
- Zhuofan Chen (ORCID: https://orcid.org/0000-0002-3341-1485)
- Dongsheng Yu
- Yihan Xing (ORCID: https://orcid.org/0000-0001-7594-3642)
- Ye Li
Institutions
- Sun Yat-sen University (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1186/s13018-025-06503-7
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China