Healthy lifestyle factors outweigh influence of APOE genetic risk on extending cognitively healthy life expectancy
These results highlight the potential of public health interventions, i.e., lifestyle modifications, on delaying the onset of cognitive impairment and compressing the lifespan with dementia and cognitive impairment, regardless of genetic predispositions.
Authors
- Xurui Jin
- Sebastian Walsh (ORCID: https://orcid.org/0000-0001-8894-5006)
- Mingzhi Yu (ORCID: https://orcid.org/0009-0001-2098-8082)
- Yuling Jiang
- Longbing Ren (ORCID: https://orcid.org/0000-0003-2462-2421)
- Quincy M. Samus (ORCID: https://orcid.org/0000-0001-8218-7769)
- Shaojie Li (ORCID: https://orcid.org/0000-0002-7203-2488)
- Yao Yao (ORCID: https://orcid.org/0000-0002-4979-7204)
- Fan Hu (ORCID: https://orcid.org/0000-0002-2116-1845)
- Gill Livingston
- Yi Zeng
- Yifei Wu
- Yang Hu
Institutions
- Johns Hopkins University (US)
- Duke University (US)
- Peking University (CN)
- University of Cambridge (GB)
- Chinese PLA General Hospital (CN)
- Bridge University (SS)
- University College London (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_101957
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00