Effect of poly-L-lactic acid injections on structural and functional quality of face and body skin: a clinical study of the Ellagen implant

Objective. To evaluate structural and functional changes of facial and body skin after Ellagen filler injections. Material and methods. To achieve this objective, we established the following tasks: to measure and evaluate dynamics of key functional parameters of skin (hydration, elasticity, sebum levels and skin redness); to non-invasively assess possible structural skin changes using acoustic density and thickness of dermis and hypodermis; to evaluate dynamics of effects throughout 18 months after treatment. This was a prospective, interventional, single-center, open-label study in a single group of patients. Parameters measured at the study stages were compared with those at the screening stage (1, 3, 6, 12, and 18 months after treatment). Results. The study showed the high efficiency and safety of the poly-L-lactic acid based Ellagen biostimulating implant in correcting age-related skin changes on the face, neck and trunk. The data obtained indicate that therapy with Ellagen contributes to a significant improvement in key biophysical parameters of the skin, such as moisture, elasticity, thickness and density of the dermis and hypodermis. Conclusion. The preservation of positive functional and structural changes in the skin after 18 months of treatment confirms that Ellagen is an effective and promising means for biostimulation of the skin, providing a long-term improvement in its quality and appearance.