Regional tau burden emerges following beta‐amyloid chronicity timeline in the Down syndrome population
This work supports previous findings that NFT regions I-II demonstrate earlier increases to flortaucipir SUVR than other NFT regions when using a standardized temporal model for Aβ onset.
Authors
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Benjamin L. Handen (ORCID: https://orcid.org/0000-0001-9550-1665)
- Tim D. Fryer (ORCID: https://orcid.org/0000-0003-1555-9790)
- Charles M. Laymon (ORCID: https://orcid.org/0000-0002-5966-7219)
- Tobey J. Betthauser (ORCID: https://orcid.org/0000-0001-8856-1352)
- Brecca Bettcher
- Andrew K McVea (ORCID: https://orcid.org/0009-0008-4525-2793)
- Patrick J. Lao (ORCID: https://orcid.org/0000-0003-2243-3547)
- Matthew Zammit (ORCID: https://orcid.org/0000-0001-8966-8397)
- Sigan L. Hartley (ORCID: https://orcid.org/0000-0002-0186-6282)
- Max McLachlan (ORCID: https://orcid.org/0000-0003-1801-7233)
- Julie C. Price
- Beau M. Ances (ORCID: https://orcid.org/0000-0003-3862-7397)
- Shahid Zaman
- David B. Keator (ORCID: https://orcid.org/0000-0001-5281-5576)
- Bradley T Christian
- Lisette LeMerise (ORCID: https://orcid.org/0009-0001-4443-0673)
- Adam Brickman
- Elizabeth Head
- Charles K Stone
- Mark Mapstone
- Jeremy P. Rouanet
- H. Diana Rosas
- Sterling C. Johnson
Institutions
- NewYork–Presbyterian Hospital (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- University of Pittsburgh (US)
- University of California, Irvine (US)
- Washington University in St. Louis (US)
- University of Cambridge (GB)
- New York Hospital Queens (US)
- Massachusetts General Hospital (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_110862
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00