Validation of Ex L2/3 IT RORB GRIN1 Subpopulation Vulnerability in the Superior Temporal Gyrus Across Amnestic and Atypical Alzheimer's Disease Presentations

Our preliminary data suggests that the Ex L2/3 IT RORB GRIN1 subpopulation is depleted and selectively vulnerable to AD-related tau pathology in excitatory neurons across both amnestic AD and atypical AD presentations. Ongoing analysis will further strengthen our findings. These results highlight the critical role of cell type-specific approaches in comprehending disease heterogeneity and progression.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70861_108544
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Validation of Ex L2/3 IT RORB GRIN1 Subpopulation Vulnerability in the Superior Temporal Gyrus Across Amnestic and Atypical Alzheimer's Disease Presentations

Lea T. Grinberg, Ian Oh, Song Hua Li, Liara Rizzi et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Validation of Ex L2/3 IT RORB GRIN1 Subpopulation Vulnerability in the Superior Temporal Gyrus Across Amnestic and Atypical Alzheimer's Disease Presentations

Lea T. Grinberg, Ian Oh, Song Hua Li, Liara Rizzi, Felipe Luiz Pereira
article en

Abstract

Our preliminary data suggests that the Ex L2/3 IT RORB GRIN1 subpopulation is depleted and selectively vulnerable to AD-related tau pathology in excitatory neurons across both amnestic AD and atypical AD presentations. Ongoing analysis will further strengthen our findings. These results highlight the critical role of cell type-specific approaches in comprehending disease heterogeneity and progression.

Alzheimer s & DementiaVol. 21(S7)
Universidade de São Paulo (BR), University of California, San Francisco (US), Microsoft (Brazil) (BR), University Memory and Aging Center (US)
Openalex Percentile: Top 36%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
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Validation of Ex L2/3 IT RORB GRIN1 Subpopulation Vulnerability in the Superior Temporal Gyrus Across Amnestic and Atypical Alzheimer's Disease Presentations — Lea T. Grinberg, Ian Oh, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS