Engagement of Amyloid‐Targeting Antibodies on Native Human and Murine Cerebral Amyloid Angiopathy CAA Containing Vessels
Characterization of Aβ peptides in isolated cerebral vessels confirmed a predominance of Aβ<sub>40</sub> and low levels of truncated Aβ<sub>p3-x</sub>. Higher levels of CAA target engagement were observed for amyloid-targeting antibodies that bind deposited full-length Aβ (gantenerumab, lecanemab, bapinezumab) as opposed to truncated and pyro-glu modified Aβ (donanemab). These results suggest factors other than ability to bind CAA are important for the manifestation of ARIA.
Authors
- John A. Tzaferis
- Ronald B. DeMattos (ORCID: https://orcid.org/0009-0008-7651-1807)
- Justin T. Hole
- Deon Turner
Institutions
- Eli Lilly (United States) (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108893
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00