Plasma <i>p</i> ‐tau217 Predicting Concurrent Aβ and Longitudinal Tau Across the Brain

Using two independent samples, we found strong evidence suggesting that blood-based biomarker of AD can be used to infer brain-wide neuropathology. High plasma p -tau217 reflects Aβ deposition across the brain in cognitively unimpaired older adults and predicts future brain-wide tau accumulation across AD continuum. Plasma p -tau217, likely indexing the pre-tangle form of tauopathy, may signal an earlier event prior to measurable PET change and can reflect Aβ plaques and the emergence of neurofibrillary tangles in the brain. Our findings highlight the great potential of plasma p -tau217 in early detection and disease monitoring of AD.