BrainAge moderates associations between AD biomarkers and cognitive decline: findings from A4/LEARN and the Harvard Aging Brain Study
BrainAge<sub>delta</sub> is significantly associated with Aβ and tau burden and moderates their association with cognitive decline, supporting previous literature suggesting that BrainAge is a robust marker of brain health. Prioritizing individuals with worse BrainAge for clinical trials could not only effectively reduce screen fails (estimates forthcoming) but is a potentially feasible approach given that it can be calculated from a single T1-weighted MRI scan. These findings also highlight the importance of age-independent neurodegeneration patterns to contribute unique signal in models of brain health and pathological progression.
Authors
- Aaron P. Schultz (ORCID: https://orcid.org/0000-0002-0418-0999)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Michael Donohue (ORCID: https://orcid.org/0000-0001-6026-2238)
- Rachel F. Buckley (ORCID: https://orcid.org/0000-0002-5356-5537)
- Ibai Díez (ORCID: https://orcid.org/0000-0001-5769-0178)
- Jorge García Condado (ORCID: https://orcid.org/0000-0002-9463-1924)
- Gillian Coughlan (ORCID: https://orcid.org/0000-0003-1806-702X)
- Colin Birkenbihl (ORCID: https://orcid.org/0000-0002-7212-7700)
- Asier Erramuzpe (ORCID: https://orcid.org/0000-0002-9402-2184)
- D. Rentz
- Jasmeer P. Chhatwal (ORCID: https://orcid.org/0000-0002-7792-1698)
- Hannah M Klinger
- Cortes Jesús
- R. A. Sperling
- Hyun‐Sik Yang
- Iñigo Tellaetxe Elorriaga
- Keith A. Johnson
- Michael J. Properzi
- Mabel Seto
Institutions
- Ikerbasque (ES)
- University of Southern California (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- The University of Melbourne (AU)
- University of the Basque Country (ES)
- Vanderbilt University (US)
- Massachusetts General Hospital (US)
- BioCruces Health research Institute (ES)
- Euskadiko Parke Teknologikoa (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_109903
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00