Metabolic and Vascular Dysfunction of Brain Regions in Alzheimer's Disease and Related Dementia
Our findings show that MVD of the at-risk brain regions depends on sex, APOE status, age, and disease stage. Moreover, our data reveals that MVD patterns can provide a sensitive diagnostic tool for early diagnosis of ADRD, which may improve patient monitoring, stratification, and therapeutic testing.
Authors
- Scott A. Persohn
- Paul Salama (ORCID: https://orcid.org/0000-0002-7643-3879)
- Ravi S. Pandey (ORCID: https://orcid.org/0000-0001-9567-2851)
- Paul R. Territo (ORCID: https://orcid.org/0000-0003-0460-332X)
- Juan Antonio K. Chong Chie (ORCID: https://orcid.org/0000-0003-3111-2294)
- Olivia R. Simcox
Institutions
- University of Indianapolis (US)
- Jackson Laboratory (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Marian University - Indiana (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_110124
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00