Understanding the Physiological Behavior of Disc Cells in an In Vitro Imitation of the Healthy and Degenerated Disc Niche
The media formulations developed here can provide more appropriate environmental conditions in vitro, mimicking more closely the in vivo conditions observed within healthy and degenerate IVDs. The application of which can provide more appropriate culture conditions to test potential therapeutic approaches and understand more fully the pathogenesis of disease using in vitro and ex vivo models.
Authors
- Exarchos Kanelis (ORCID: https://orcid.org/0000-0002-2059-1480)
- Joseph Snuggs (ORCID: https://orcid.org/0000-0002-0200-4596)
- Shaghayegh Basatvat (ORCID: https://orcid.org/0000-0001-6201-4588)
- Leonidas G. Alexopoulos (ORCID: https://orcid.org/0000-0003-0425-166X)
- Marianna A. Tryfonidou (ORCID: https://orcid.org/0000-0002-2333-7162)
- Christine Lyn Le Maitre (ORCID: https://orcid.org/0000-0003-4489-7107)
- Abbie Binch
Institutions
- National Technical University of Athens (GR)
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- Regenerative Medicine Institute (MX)
- Sheffield Hallam University (GB)
- University of Sheffield (GB)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/jsp2.70153
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00