Structure‐specific Mini‐prion Model for Alzheimer's Disease Tau Fibrils
The mini-AD seeds and the seeded fibrils, with their remarkable templating capabilities, offer a novel strategy to design model tau fibril prions to achieve and investigate the seeded propagation of tau in vitro, in cellular and animal models.
Authors
- Athena Quddus
- Vishnu Vijayan (ORCID: https://orcid.org/0000-0003-2793-6127)
- K. Nakagawa
- Michael Vigers (ORCID: https://orcid.org/0000-0002-5685-6153)
- Gregory E. Merz (ORCID: https://orcid.org/0000-0003-0842-4935)
- Andrew P. Longhini (ORCID: https://orcid.org/0000-0002-0599-5030)
- Daniel R. Southworth (ORCID: https://orcid.org/0000-0001-7108-9389)
- Songi Han
- Kenneth S. Kosik
Institutions
- Northwestern University (US)
- University of California, Santa Barbara (US)
- University of California, San Francisco (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108374
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00