Integrin-Mediated TIMP1 Signaling Reprograms Liver Macrophages and Accelerates Colorectal Cancer Metastasis
CRC-derived TIMP1 remodels liver macrophages via the CD63/β1-integrin-AKT/mTOR pathway to promote a hepatic pre-metastatic niche. Pharmacologic inhibition of this signaling axis with the integrin antagonist cilengitide suppressed macrophage M2 markers and liver colonization in mice, supporting TIMP1-integrin signaling as a potential therapeutic target.
Authors
- Guoli Sheng
- Zhaoxu Zheng (ORCID: https://orcid.org/0000-0002-6585-5785)
- Guoxin Li (ORCID: https://orcid.org/0000-0001-8384-0002)
- L Zhao
- Jianfeng Liu (ORCID: https://orcid.org/0000-0003-0541-5072)
- Pu Cheng (ORCID: https://orcid.org/0000-0002-0226-3467)
- M Z Han
- Lin Wang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Cancer Center (US)
- Beijing Tsinghua Chang Gung Hospital (CN)
Publication Details
- Journal
- Cells
- Published
- 2025-12-23
- DOI
- https://doi.org/10.3390/cells15010029
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80